RAF Typhoon fighter aircraft have operated alongside France's air force in a joint strike on an underground arms cache in Syrian territory used by the Daesh militant organization, according to the British defence ministry.
The location, identified by surveillance, was thought to be storing arms and explosives, the statement said, and was positioned in mountains just north of Palmyra in central Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to hit a series of access tunnels down to the depot... early reports indicate the objective was successfully hit," the ministry announced.
There was no indication of any civilian impact in the attack late on Saturday and every plane involved returned safely, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - referred to as ISIS - enforced militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates the UK's leading role, and determination to stand shoulder to shoulder with our partners, to stamp out any re-emergence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
British military aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted resurgence" of the group subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank every member of British forces participating in this mission for their professionalism and their bravery," Healey said. "Including them were a great many UK service members stationed over Christmas and New Year. This action, to eliminate terrorist threats who pose a risk to our safety, demonstrates how British military are always on standby, throughout the year, keeping Britain secure within its borders and influential overseas."
In December, the United States armed forces executed what it described as a "large-scale strike" against Islamic State objectives in Syria, following an ambush claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still has between 5,000 and 7,000 fighters in both countries.